Is Novavax the Next COVID-19 Vaccine on the Block? How It Works & Why It’s Important

It will likely take a vaccine cheaper than Moderna's and Pfizer's to save the world.

An illustration picture shows vials with Covid-19 Vaccine stickers attached and syringes with the logo of US biotech company Novavax, on November 17, 2020. JUSTIN TALLIS/AFP via Getty Images

The global COVID-19 vaccine campaign is getting increasingly complicated. While the Moderna (MRNA) and Pfizer (PFE)/BioNTech vaccines are rolling out in full speed in the U.S., public health experts have agreed that it will likely take a less expensive and easier to transport vaccine to get the rest of the world inoculated. Just a few weeks ago, hopes were high on shots made by AstraZeneca and Johnson & Johnson. But now both are facing regulatory scrutiny after a small number of early vaccine recipients developed a dangerous blood clotting condition, leaving the world anxiously waiting for the next working vaccine on the block.

Sign Up For Our Daily Newsletter

By clicking submit, you agree to our <a href="http://observermedia.com/terms">terms of service</a> and acknowledge we may use your information to send you emails, product samples, and promotions on this website and other properties. You can opt out anytime.

See all of our newsletters

The most promising candidate in the market right now is a new type of COVID-19 vaccine developed by Maryland-based biotech company Novavax.

Like Moderna and Pfizer, Novavax was among the first pharma companies to develop a COVID-19 vaccine even before the virus was declared a global pandemic. The firm announced its vaccine effort in January 2020, launched global phase 1 clinical trials in May, and quickly moved into a phase 2 trial in South Africa in August and a phase 3 trial in the U.K. in September. A large-scale phase 3 trial in the U.S. was launched in December.

Last month, Novavax reported impressive results from the U.K. and South Africa trials. Its vaccine was found to be 96 percent effective against the original coronavirus, 86 percent against the B.117 variant prevalent in the U.K. and 49 percent against the dangerous B.1.351 variant, which was first detected in South Africa. Alarmed by the reduced efficacy rates on variants, the company is developing a new vaccine specifically tailored to the South African strain.

Novavax is also exploring the potential for combining NVX-Cov2373 with its flu vaccine candidate NanoFlu. “A COVID-19/flu combo vaccine could be a commercial winner if annual COVID-19 vaccinations are needed as many anticipate will be the case,” wrote Motley Fool analyst Keith Speights, who covers health tech and pharma stocks.

Novavax’s vaccine, officially known as NVX-CoV2373, is protein-based. It uses a lab-made version of the spike protein of the original coronavirus (which won’t get you sick) to train the immune system to produce antibodies to block the harmful virus from entering cells when exposed. Like many other COVID-19 vaccines, it requires two shots injected about three weeks apart.

A major advantage is that Novavax’s vaccine can stay stable for up to three months in at normal refrigerator temperature, making it easier and cheaper to transport and store than mRNA-based shots.

Novavax has an agreement with the U.S. government to supply 100 million doses of NVX-CoV2373 once it’s authorized for emergency use. The U.S. trial is expected to report results this quarter, and an FDA EUA application will follow.

Is Novavax the Next COVID-19 Vaccine on the Block? How It Works & Why It’s Important